Ercole I. (1431-1505), Duke of Ferrara, Reggio and Modena

Leonora (or Eleonora) of Aragon (1450-1493), daughter of King Ferrante of Naples († 1494)

Gian Francesco II. Gonzaga (1466-1519), Margrave of Mantua

1. her daughter Leonora or Eleonora, born on 31. December 1493, deceased in 1550; on 2. March 1505 she became married to Francesco Maria della Rovere (1490-1538), Duke of Urbino
2. her daughter Margherita, born on 13. July 1496, deceased on 23. September 1496
3. her son Federigo II., Margrave of Mantua of 1519-1531; Duke of Mantua 1531-1540; born on 17. May 1500, deceased on 28. June 1540
4. her daughter Livia, born in 1501, deceased in January 1508
5. her daughter Ippolita, born on 13. November 1503, deceased on 16. March 1580, since 1511 nun in the Dominican Convent of St. Vincent
6. her son Ercole (in actual fact: Louis or Alvise), born on 22. November 1505, deceased on 2. March 1563, Cardinal since 1527
7. her son Ferrante, Duke of Guastalla, born on 28. January 1507, deceased am 15. November 1557; in April 1531 he married the rich Neapolitan heiress Isabella of Capua, a daughter of the Duke of Tremoli; they had 11 children, of whom five, Filippo, Ercole, Anna, Geronima and Maria, died in their infancy; the following children reached the adulthood: Ippolita (1535-1563), Cesare (1534/37-1575), Francesco (1538-1566), Andrea (1539-1586), Gian Vincenzo (1540-1591) and Ottavio (1543-1583)
8. her daughter Livia, born in 1508, deceased in 1569, since 1516 nun in a Franciscan convent, as Sister Paola she was highly regarded by the citizens of Mantua

• Maike Vogt-Luerssen: Frauen in der Renaissance – 30 Einzelschicksale (in German) (biography about Isabella d'Este, pp. 91-109)
• Maike Vogt-Luerssen: Die Sforza III: Isabella von Aragon und ihr Hofmaler Leonardo da Vinci (in German). Norderstedt 2010
• Maike Vogt-Luerssen: Lucrezia Borgia – The Life of a Pope's Daughter in the Renaissance

Video tip: Mantua, Italy, walking tour with local guide