Duke Charles II. of Lorraine (1543-1608), son of the famous Christina of Denmark († 1590)

Claude of France (1548-1575), daughter of the French King Henry II. († 1559) and the famous Catherine de' Medici († 1589)

Grand Duke Ferdinand I. de' Medici of Tuscany (1549-1609); marriage on 3. May 1589

1. her son Cosimo II., born on 15. May 1590, deceased on 28. February 1621
2. her daughter Eleonora, born on 10. November 1591, deceased on 21. November 1617
3. her daughter Caterina, born on 2. May 1593, deceased on 17. April 1629 (according to the inscription on her grave in the church San Lorenzo in Florence she died on 15. May 1628); she was married to Duke Ferdinand I. Gonzaga (1587-1626) of Mantua and Montferrat in 1617; no children
4. her son Francesco, born on 24. May 1594, deceased on 17. May 1614 (according to the inscription on his grave in the church San Lorenzo in Florence he died on 16. January 1614)
5. her son Carlo, born on 19. March 1596, deceased on 17. June 1666 (according to the inscription on his grave in the church San Lorenzo in Florence he died on 15. July 1666)
6. her son Filippo, born on 9. April 1598, deceased on 27. March 1602
7. her son Lorenzo, born on 1. August 1599, deceased on 16. November 1648 (according to the inscription on his grave in the church San Lorenzo in Florence he died on 17. December 1648)
8. her daughter Maria Magdalena, born on 28. June 1600, deceased on 16. November 1633
9. her daughter Claudia, born on 20. June 1604, deceased on 25. December 1648