Maria Teresa hatte mit ihrem Gatten, dem französischen König Ludwig XIV., sechs Kinder, von denen jedoch nur ihr ältestes Kind, ihr Sohn Ludwig (1661-1711), das Erwachsenenalter erreichte. Ihre Kinder waren: 1. Ludwig oder Louis, geboren am 1. November 1661, gestorben am 14. April 1711; 2. Anne Élisabeth, geboren am 18. November 1662, gestorben am 30. Dezember 1662 ["The little Princess was only a few weeks old, when she died, a victim to the ignorance of the Court physicians who, as usual, insisted on bleeding her]; 3. Marie Anne, geboren am 16. November 1664, gestorben am 26. Dezember 1664 [Maria Teresa war vor der Geburt sehr krank geworden: "An attack of fever brought on a premature confinement, and for some weeks the Queen's life was in imminent danger ... Mademoiselle [Anne Marie Louise d'Orléans] describes the crowds which thronged the sick chamber ... Marie Thérèse eventually recovered, but the baby, a little girl who was christened Marie Anne, and had Madame [Henriette Anna Stuart, die Herzogin von Orléans] for her godmother, died in December."]; 4. Marie-Thérèse, geboren am 2. Januar 1667, gestorben am 1. März 1672; 5. Philippe Charles, geboren am 2. August 1668 [in: Julia Mary Cartwright Ady: Madame, a life of Henrietta, daughter of Charles I. and Duchess of Orleans, id., p. 294], gestorben am 10. Juli 1671; und 6. Louis François, geboren am 14. Juni 1672, gestorben am 4. November 1672. Laut der Mätresse ihres Gatten, der Madame de Montespan, soll Maria Teresa insgesamt fünf Töchter auf die Welt gebracht haben. Da die Geburt von Töchtern auch im 17. Jahrhundert zu keiner großen Freude Anlass gab, könnten die Informationen von zwei Töchtern verloren gegangen sein. Eine Tochter könnte schon wenige Tage oder am Tag der Geburt gestorben sein, die andere Tochter wird von Madame de Montespan in ihren Memoiren als missgestaltet bezeichnet. Sie soll - wie es Tradition für viele Jahrhunderte in den adligen Kreisen war -, an eine Bauernfamilie gegeben worden sein, wo man vermutlich hoffte, dass sie dort aus hygienischen Gründen bald sterben würde. Laut Madame de Montespan überlebte die kleine Prinzessin jedoch die gesundheitlich gefährlichen Jahre auf dem Lande und wurde schließlich in ein Kloster gesteckt, wo sie jene - aus Neugierde - aufgesucht hätte.
Als dieses obige Porträt von ihr und ihrem ältesten Sohn Ludwig erstellt wurde, hatte sie schon ein Kind, ihre Tochter Anne Élisabeth, verloren, die nur vom 18. November 1662 bis zum 30. Dezember 1662 gelebt hatte.
Die Geburt ihres ältesten Sohnes, des Dauphins Ludwig, der das Lieblingskind seines Vaters und seiner Mutter werden sollte: "When the child came into the world, at five minutes before midday on the first of November [1661] ... he was heir-presumptive of the two great kingdoms of France and Spain [sein Großvater mütterlicherseits, Philipp IV. von Spanien, hatte gerade seinen bisher letzten Sohn verloren] ...The queen [Maria Teresa] was very ill at her delivery and in peril of her life. While she was in her great pains the king [Ludwig XIV.] seemed so much distressed and so keenly touched with sorrow that he left no room for doubt that the love he felt for her was deeper in his heart than that for others [z. B. für Mademoiselle de La Vallière]. He went at five o'clock in the morning to confess and receive the communion; and after imploring divine protection, he gave himself wholly to the care of assisting her who, suffering for him, gave him at every moment signs of tenderness; so that the precious infant, entering the world, was in himself not only a tie that bound still closer the two royal persons from whom he drew his life, but in the act of being born he became, by the pain and joy he gave them, a mark infallible of their affection." (in: Memoirs of Madame de Motteville, Volume 3, id., p. 268).
Maria Teresa im November 1664, bei der Geburt ihres dritten Kindes, ihrer Tochter Marie Anne: "On the 4th of November [1664] the queen was taken dangerously ill. Her illness began with a tertian fever attended by unfortunate accidents. She had great pains in the legs, and these, which were very violent, were followed by her delivery at eight months of a princess which lived but a few days. The next day, the queen had convulsions which made them fear her death. The king ... showed very tender sentiments for the queen. He wept, and his grief, besides the marks he gave her of his affection, he showed his faith. He distributed quantities of money to the poor, and he sent to the prisons to release the prisoners; he made vows for the life of a queen he esteemed for her virtue ... He said to the Maréchal de Villeroy, while she was in travail, that although it would be a great misfortune for him to lose a child, he could be consoled for that, provided God did him the favour to preserve the queen's life, and also that his child could be baptized. God restored the queen to the king, the queen-mother, and to France. She recovered on the 18th of November, after taking an emetic." (in: Memoirs of Madame de Motteville, Volume 3, id., pp. 308-309).